To ensure nationwide interoperability of biomedical data, a variety of technical and semantic challenges need to be addressed, ranging from the agreement on common data standards, to building a federated secure IT infrastructure. To tackle these challenges, SIB’s Personalized Health Informatics Group sets-up and coordinates expert working groups. The members of these teams aim to develop standards and pragmatic, sustainable “best practices” covering all key dimensions of interoperability in the realm of the Swiss Personalized Health Network Initiative.