SWISSHEART Failure Network (SHFN)

Presenters: Professor Christian M. Matter, University Hospital Zurich, (SPHN); Professor Joachim M. Buhmann, ETH Zurich (PHRT); Dr. Antje Thien, University Hospital Zurich

About this Project: Heart failure (HF) affects one in five adults over 40 years of age and confers a dismal prognosis. In half of all HF patients, HF is caused by a heart attack. Yet, the triggers of acute HF, the prediction of patients at risk for HF and the drivers of HF progression remain poorly understood. Moreover, the combined analysis of risk factors, electrocardiograms, imaging and laboratory data is complex, multidimensional and not standardized in Switzerland. Machine Learning (ML) can deal with such complexity and offers an automated way to discover key patterns in big data sets of clinical and diagnostic nature. ML methods bear a great potential to improve diagnostic and prognostic accuracy, thereby allowing a more tailored management of patients with HF.

The SWISSHEART Failure Registry will collect clinical, laboratory, electrocardiogram and imaging data of patients at risk for HF (patients with heart attack) and patients hospitalized for acute HF. We then integrate multi-dimensional features from these patient data into machine learning-based diagnostic and risk scores. A magnetic resonance imaging-based disease simulator reduced to a 4D digital heart model will be personalized based on cardiac ultrasound and electrocardiogram data.

Building this national collaborative SWISSHEART Failure Network will set the stage for standardized nationwide cardiovascular research in Switzerland and strengthen synergies between cardiology experts at Universities and computer science experts at ETH. We anticipate that this project will improve prediction and prevention of HF and decrease HF progression in specific patients.

Date: 17 March 2021

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